A Metabolite of Vitamin D, Effective on Intestine*
نویسندگان
چکیده
A polar metabolite of 24,ZSdihydroxyvitamin DS has been generated both in vivo in rats from 25-hydroxyvitamin D3 and in vitro from 24,25-dihydroxyvitamin DS with chicken kidney homogenates. This metabolite has been isolated in pure form and identified as 1,24,25-trihydroxyvitamin Da by means of ultraviolet absorption spectrophotometry, mass spectrometry and its reactivity to periodate treatment. 1,24,25-Trihydroxyvitamin DS is 60% as active as vitamin Da in curing rickets. It is less active on a weight basis than 1,ZSdihydroxyvitamin Da in stimulating and sustaining intestinal calcium transport and bone calcium mobilization but appears to have preferential action on the intestine.
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تاریخ انتشار 2002